This 24 y/o HIV positive male developed sudden change in mental status. Selected images from his pre and post contrast CT and MRI studies shown above demonstrate lesions in the posterior parieto-occipital region with considerable surrounding edema and mass effect but with only minimal peripheral enhancement. An infectious etiology especially toxoplasmosis was suspected and confirmed by stereotactic biopsy.

  1. Brightbill TC, Post MJ, Hensley GT, Ruiz A. MR of Toxoplasma encephalitis: signal characteristics on T2-weighted images and pathologic correlation. J Comput Assist Tomogr 1996 May-Jun;20(3):417-22 PMID:8626904
  2. Laissy JP, Soyer P, Tebboune J, Gay-Depassier P, Casalino E, Lariven S, Sibert A, Menu Y. Contrast-enhanced fast MRI in differentiating brain toxoplasmosis and lymphoma in AIDS patients. J Comput Assist Tomogr 1994 Sep-Oct;18(5):714-8 PMID:8089317
  3. Levy RM, Russell E, Yungbluth M, Hidvegi DF, Brody BA, Dal Canto MC. The efficacy of image-guided stereotactic brain biopsy in neurologically symptomatic acquired immunodeficiency syndrome patients. Neurosurgery 1992 Feb;30(2):186-9; discussion 189-90 PMID:1545885
  4. Weller IV, Williams IG. ABC of AIDS: Treatment of infections. BMJ 2001 Jun 2;322(7298):1350-4 PMID:11387187
  5. Cohen BA. Neurologic manifestations of toxoplasmosis in AIDS. Semin Neurol 1999;19(2):201-11 PMID:10718541
  6. Dunn IJ, Palmer PE. Toxoplasmosis. Semin Roentgenol 1998 Jan;33(1):81-5 PMID:9516691
  7. Ramsey RG, Gean AD. Neuroimaging of AIDS. I. Central nervous system toxoplasmosis. Neuroimaging Clin N Am 1997 May;7(2):171-86 PMID:9113684
  8. Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis 1992 Aug;15(2):211-22 PMID:1520757
  9. Cassidy CM. Central nervous system toxoplasmosis in the AIDS patient. J Assoc Nurses AIDS Care 1994 Jul-Aug;5(4):14-8, 27; quiz 19-20 PMID:7948968
  10. Mariuz PR, Luft BJ. Toxoplasmic encephalitis. AIDS Clin Rev 1992;:105-30 PMID:1606055
  11. Ammassari A, Murri R, Cingolani A, De Luca A, Antinori A. AIDS-associated cerebral toxoplasmosis: an update on diagnosis and treatment. Curr Top Microbiol Immunol 1996;219:209-22 PMID:8791702
  12. Fung HB, Kirschenbaum HL. Treatment regimens for patients with toxoplasmic encephalitis. Clin Ther 1996 Nov-Dec;18(6):1037-56; discussion 1036 PMID:9001822
  13. Provenzale JM, Jinkins JR. Brain and spine imaging findings in AIDS patients. Radiol Clin North Am 1997 Sep;35(5):1127-66 PMID:9298090
  14. Bensalem MK, Berger JR. HIV and the central nervous system. Compr Ther 2002 Spring;28(1):23-33 PMID:11894440
  15. Chiang FL, Miller BL, Chang L, McBride D, Cornford M, Mehringer CM. Fulminant cerebral lymphoma in AIDS. AJNR Am J Neuroradiol 1996 Jan;17(1):157-60 PMID:8770269

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