This 51 y/o female with a history of hepatitis and alcohol abuse was referred for abdominal CT to evaluate abnormal liver function studies. Post contrast CT images shown above demonstrate a focal area of enhancement in the posterior aspect of the right lobe of the liver. MRI of the liver both before and after Teslascan (mangafodipir) was then performed. The selected images shown above demonstrate an area of increased signal after Teslascan administration in the same area that showed increased enhancement on CT. A liver biopsy was done and the diagnosis of focal nodular hyperplasia was made.

  1. Low RN. Contrast agents for MR imaging of the liver. J Magn Reson Imaging 1997 Jan-Feb;7(1):56-67 UI:97191648
  2. Clement O, Siauve N, Cuenod CA, Vuillemin-Bodaghi V, Leconte I, Frija G. Mechanisms of action of liver contrast agents: impact for clinical use. J Comput Assist Tomogr 1999 Nov;23 Suppl 1:S45-52 UI:20074076
  3. Mathieu D, Coffin C, Kobeiter H, Caseiro-Alves F, Mahfouz A, Rahmouni A, Diche T. Unexpected MR-T1 enhancement of endocrine liver metastases with mangafodipir. J Magn Reson Imaging 1999 Aug;10(2):193-5 UI:99369738
  4. Coffin CM, Diche T, Mahfouz A, Alexandre M, Caseiro-Alves F, Rahmouni A, Vasile N, Mathieu D. Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging. Eur Radiol 1999;9(3):444-9 UI:99187366
  5. Wang C, Gordon PB, Hustvedt SO, Grant D, Sterud AT, Martinsen I, Ahlstrom H, Hemmingsson A. MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta Radiol 1997 Jul;38(4 Pt 2):665-76 UI:97388729
  6. Murakami T, Baron RL, Peterson MS, Oliver JH 3rd, Davis PL, Confer SR, Federle MP. Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP). Radiology 1996 Jul;200(1):69-77 UI:96257142
  7. Wang C, Gordon PB, Hustvedt SO, Grant D, Sterud AT, Martinsen I, Ahlstrom H, Hemmingsson A. MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta Radiol 1997 Jul;38(4 Pt 2):665-76 UI:97388729
  8. Vogl TJ, Hamm B, Schnell B, McMahon C, Branding G, Lissner J, Wolf KJ. Mn-DPDP enhancement patterns of hepatocellular lesions on MR images. J Magn Reson Imaging 1993 Jan-Feb;3(1):51-8 UI:93153128
  9. Hamm B, Vogl TJ, Branding G, Schnell B, Taupitz M, Wolf KJ, Lissner J. Focal liver lesions: MR imaging with Mn-DPDP--initial clinical results in 40 patients. Radiology 1992 Jan;182(1):167-74 UI:92080696
    Comment in: Radiology 1992 Jan;182(1):12-4

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