1.  ELIZABETH¹ WIRTHLEY.  She married JOHN APPLEGATE, son of THOMAS APPLEGATE and JOANNA GIBBONS.
 
Children of ELIZABETH WIRTHLEY and JOHN APPLEGATE are:
2. i. JOHN² APPLEGATE, b. Abt. 1721; d. 1788.
 ii. BENJAMIN APPLEGATE, b. Abt. 1703; d. 1780; m. ELIZABETH PARENT, July 18, 1729, Middlesex Co., New Jersey.
 iii. ABIGAIL APPLEGATE, m. MARTIN.
 iv. URSULA APPLEGATE, m. BENNETT.
 v. ELSIE APPLEGATE, m. CLAYTON.
 vi. NAOMI APPLEGATE.
 vii. ANN APPLEGATE.
 viii. THOMAS APPLEGATE, b. Abt. 1705; d. 1787; m. HANNAH DISBROUGH.
 ix. ZEBULON APPLEGATE, b. Abt. 1715; d. November 1777; m. RUTH.
 x. SARAH APPLEGATE, b. Abt. 1700; d. April 29, 1741.
 

2.  JOHN² APPLEGATE (ELIZABETH1 WIRTHLEY) was born Abt. 1721, and died 1788.  He married HANNA.
 
Children of JOHN APPLEGATE and HANNA are:
 i. ELIZABETH³ APPLEGATE, d. Bef. 1787; m. JEFFERS.
 ii. JOHN APPLEGATE.
 iii. KESIAH APPLEGATE.
 iv. WILLIAM APPLEGATE.
 v. SAMUEL APPLEGATE, b. January 1746, Shrewsbury, NJ; d. 1824; m. JANE SCROGGINS, January 20, 1777.
 vi. REBECCA APPLEGATE, b. 1749, Shrewsbury, NJ.
 vii. HANNAH APPLEGATE, b. 1752, Shrewsbury, NJ.
3. viii. ISRAEL APPLEGATE, b. Abt. 1756; d. 1833.
 

3.  ISRAEL³ APPLEGATE (JOHN2, ELIZABETH1 WIRTHLEY) was born Abt. 1756, and died 1833.  He married FRANCES EGBERT.
 
Children of ISRAEL APPLEGATE and FRANCES EGBERT are:
 i. HENRY APPLEGATE, b. September 08, 1794, Milfordsburg, Allegheny Co., Pennsylvania; d. December 04, 1881, Jefferson township, Lee Co., Iowa.
 ii. ISRAEL APPLEGATEII, b. January 10, 1790; d. January 02, 1870, Green township, Hamilton Co., Ohio.
 iii. SARAH APPLEGATE.
 iv. BETTY APPLEGATE.
 v. MARGARET APPLEGATE, b. December 11, 1789.