Inversion of Chromosome 16
This image shows an  inversion of chromosome 16.   By looking carefully at the pair of 16, you will see that the chromosome on the right looks different from the one on the left. The left one is normal and the right one is inverted near the centromere.  Inversions, by definition, do not involve loss or gain of chromosomal material. If the breakpoints of the inversion do not disrupt genes they may not have an associated phenotype.

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Image from UW Pathology Cytogenetics Gallery