CLEAVAGE AND DEPROTECTION OF PEPTIDE-RESINS

WITH HALOTRIALKYLSILANES.

A BETTER ALTERNATIVE TO HF CLEAVAGE OF PEPTIDE RESINS

PROCEDURE DEVELOPED BY

JOHN L. HUGHES AND ERIC J. LEOPOLD


CONTENTS OF THIS SITE 

BACKGROUND

HF vs BROMOTRIMETHYLSILANE (TMS BROMIDE)

TMS BROMIDE vs TMS CHLORIDE

APPARATUS

TECHNIQUE AND NOTES

LIMITATIONS OF HALOTRIALKYLSILANES

REFERENCES


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Last Modified 7/27/2004

Other sites made by Eric J. Leopold