Syracuse to Hoffmans (Schenectady)

There are crossovers at CP 285 (MP 286.0), where a 10,300 ft. siding starts, the former location of the Amtrak porta-cabin on the south side of the line at Syracuse (MP 285.5), on the far east side of the city, dual road bridges overhead, a spur trailing in from the southwest, MP 285.0, where speeds become 79-60-50, DeWitt Yard (MP 284.0) on the north side of the line, and a signal bridge at CP 283 (MP 283.8), where the siding ends. The double track line heads east, past a grade crossing, Minoa, Intermediate Signals at Kirkville (MP 280.1), a road alongside to the south, a grade crossing, detectors at MP 280.0, where the speed limits become 79-70-60-50, crossovers and signal bridges at CP 278 (MP 278.4), a grade crossing, Sullivan, three grade crossings, crossovers at CP 270 (MP 270.3), Canastota (MP 269.0), where the Lehigh Valley line to Oswego once crossed at grade, MP 268, a road bridge overhead, Wampsville, where the West Shore once connected in (with a track still visible along the right-of-way) and out again, and the line turns east-northeast, crossovers at CP 266 (MP 266.0), where a 10,700ft. siding on the south side starts, Oneida, where the Ontario & Western once crossed at grade, a grade crossing, the siding ends. and crossovers at CP 263 (MP 263.8), with a grade crossing between the crossovers.

The line turns northeast, past two grade crossings, detectors at MP 262.2 ("Oneida, NY"), a grade crossing, MP 262, a grade crossing, Intermediate Signals at MP 261.x, two road bridges overhead, two grade crossings, crossovers and signal bridges at CP 257 (MP 257.0), a grade crossing, a dirt road grade crossing, and MP 255.0. Freight speeds fall to 60-50, and east-northeast again, past a bridge over a road below, crossovers at CP 251 (MP 251.6), and an old signal bridge, to Rome (MP 251.3), where the depot is on the south side and at a lower level, the line turns southeast as a line from the northwest once trailed in and an Ontario & Western branch once left to the south-southeast, past a road below, a grade crossing, Intermediate Signals at MP 250.0, where full speeds resume, and dual road bridges overhead. There are crossovers at CP 248 (MP 248.2), a grade crossing, an old signal bridge, a dirt road grade crossing, a road bridge overhead, Oriskany, MP 242.9, where speed limits fall to 70-60-50 as far as MP 242.6, past a road bridge overhead, across the bridge over the Mohawk River, detectors at MP 241.4, a grade crossing, a road bridge overhead, Wilkesboro, a dirt road grade crossing, crossovers at CP 239 (MP 239.1), where a 19,536 ft. siding starts, a road bridge overhead,  crossovers at CP 237 (MP 232.7), where speed limits fall to 60-50, the west end of the NYS&W yard on the south side, a road bridge overhead, dual road bridges overhead, the Susquehanna trails in from the south with the former Lackawanna freight yard along the NYS&W, south of the main, and the Mohawk, Adirondack & Northern (host of the Adirondack Scenic) trails in from the north, with shop and yard tracks on the north side of the line (in the vee of the MA&N), a highway bridge overhead, a road bridge overhead, former New York Central 0-6-0 6721 stuffed-and-mounted on the south side of the line at the west end of the station, the industrial city of Utica (MP 237.5), where the refurbished major brick passenger depot is on the south side of the line, with a footbridge crossing the lines to the Adirondack Scenic platform on the north side, east of the depot, and a platform with umbrella sheds on the south side, MP 237.0, where full speed limits resume, with a divided highway alongside to the south, and crossovers at CP 235 (MP 235.4), where the long siding ends with the line running along the north side of the Mohawk River.

There are more crossovers at CP 234 (MP 234.1), a road bridge overhead, a bridge over a tributary, Harbor, detectors at MP 230.0, a through truss bridge over a tributary, a dirt track grade crossing, a grade crossing, a road bridge overhead, crossovers at CP 225 (MP 225.9), where an NYC line once trailed in from the north and speed limits drop to 70-65-60-50, a dirt track grade crossing, a highway bridge overhead, Herkimer (MP 223.1), a grade crossing, and crossovers at CP 223 (MP 223.0), followed by a curve around to the east-northeast, following the river (alongside), a major highway bridge overhead, a bridge over a road, a road alongside to the south, a bridge over a tributary,  detectors at MP 220.0 ("Herkimer, NY"), Little Falls, where a branch once headed north to Salisbury Center, a curve east-southeast (where the river is not alongside to the south), crossovers at CP 218 (MP 218.3), where a 16,000 ft. siding starts and speeds fall to 70-60-50, MP 216.9, where speed limits fall to 65- 50, locks on the river to the south, a road alongside to the south, a road bridge overhead, a siding to a rail-served industry on the south side, MP 216.5, where speeds rise to 70-60-50, a road bridge overhead, a bridge over a road at the crossovers at CP 215 (MP 215.1), where the siding ends, a curve east, detectors at MP 211.1, MP 210.5, where full speed limits resume, a curve just east of south, a bridge over a stream, Fort Plain, CP 207 (MP 207.3), where an 18,200 ft. siding starts, a bridge over a tributary, speed limits of 70-60-50 between MP 205.9 and 205.4, a bridge over a stream, a road bridge overhead, an old signal bridge, crossovers at CP 203 (MP 203.7), where that siding ends with the line headed east, a bridge over a tributary, curving northeast, past a weir on the river alongside to the south, a road bridge overhead, detectors at MP 200.7 ("Fort Plain, NY"), a road alongside to the south, with the river beyond it, MP 199.6, where speed limits fall to 60-50, crossovers at CP 198 (MP 198.8), MP 198.2, where full speed limits resume, a grade crossing, a road bridge over both line and river, crossovers at CP 196 (MP 196.1), where the river is alongside to the south, Fonda, where the Fonda, Johnstown & Gloverville Railroad once trailed in from the northwest and the line turns east-southeast, still following the river (which is not always immediately alongside to the south), with speed limits of 50-45 between MP 192.8 and 192.5, detectors at MP 189.9, an old singal bridge, a curve northeast, a weir on the river on the south side, crossovers at CP 188 (MP 187.9), where a 16,200 ft. siding begins, two grade crossings, a road bridge overhead, crossovers at CP 184 (MP 184.5), where that siding ends,  speed limits of 50 mph from MP 183.0 to 181.5, and 70-60-50 thereafter, and east-southeast, past MP 180, and a bridge over a stream, to Amsterdam (MP 177.6), where there is a platform and depot on the north side of the double-track line, only.

There are detectors at MP 177.4, an old signal bridge, the river alongside to the south, a grade crossing, MP 177, MP 176, a wide road bridge overhead, crossovers and signal bridges at CP 175 (MP 175.5), where a 10,900 ft. siding begins, two grade crossings, crossovers and signal bridges at CP 173 (MP 173.2), where the siding ends, MP 172, a signal bridge, MP 171, and the junction at CP 169 (MP 169.9), with a signal bridge overhead and a road alongside to the north, where the Selkirk Branch, used by most freight trains heading for Selkirk Yard, departs to the southeast, and the passenger line, now single track, continues east-southeast.