There is a freight yard on the west side at North Jackson (MP 218.2), at the north end of which there is a wye (speed limit 30 mph) where the Grenada District heads north-northeast, while the Yazoo District turns northwest, with speed limit 10 mph. From Jackson, MS, to Memphis, TN, Amtrak trains used to use the Grenada subdivision, but now use the Yazoo subdivision further to the west, which starts out running through rolling hills, with the 10 mph ending at Stonewall Street (MP 217.6) in favor of the 79?-60 maximum speed on this district's single track, CTC, line. A 30 mph speed restriction begins at MP 217.2, rising to 40 mph at MP 215.9, past the 8,900 ft. siding at Halston (MP 214.5), to MP 212.2. There is a 9,330 ft. siding on the west side at Cynthia (MP 211.3), Green, Pocahontas, a 9,816 ft. siding on the west side at Flora Siding (MP 205.0), where the line turns north, Flora, where the siding ends, a 3,191 ft. siding on the west side at Ragin (MP 197.6), where the line turns north-northwest again, a bridge at MP 195.8 (freight speed limit 35 mph), a 3,601 ft. siding on the west side at Bentonia (MP 193.5), where there is also a detector, a 9,350 ft. siding on the east side at Anding (MP 189.7), where the line turns curvily northwest (freight speed limits 50, 40, and 50 on curves), Tinsley, where it turns north with freight speed limit40 mph, a 12,085 ft. siding on the east side at Valley (MP 180.2), where a line from Vicksburg once trailed in from the west and the line turns north-northeast, and Crupp, as the line enters the valley of the Yazoo River, where the countryside is the low-lying Mississippi Delta country, famed in the songs of the blues and country music singers.
The line passes Yazoo City (MP 175.2), where the freight speed limit is 20 mph from MP 177 to MP 172, there is a small yard on the west side and a passenger station, Mississippi Chemicals, Yazoo Junction, where a former Yazoo & Mississippi Valley line once left this former Yazoo & Mississippi Valley main line, heading north-northwest while the main line continues north-northeast, the 10,600 ft. siding on the west side at Delta (MP 169.2), Eden (MP 163.7), where the line turns north, Bee Lake (freight speed limit 40 mph on the bridge a MP 160.1), Thornton, where the line turns northeast, Good Hope, where it turns east, Mileston, where it turns north-northeast, Westfield, Shackleford, the 9,184 ft. siding on the west side at Gwyn (MP 148.3), where a branch once trailed in from the southeast and the line turns curvily north, Tchula (MP 147.8, freight speed limit 20 mph), Wyatt, a detector at MP 142.3, Keim, the 11,250 ft. siding on the west side at Cruger (MP 137.8), where the line turns north-northeast, the 4,900 ft. siding at Sidon (MP 131.0), where the line turns north, Rising Sun (MP 127.2), where the line turns northeast, South Greenwood (MP 125.1, where CTC ends and ABS begins, and the 5,350 ft. siding on the west side at Greenwood (MP 122.7, freight speed limit 20 mph through the town).
The Columbus & Greenville Railroad crosses the IC at a gated grade crossing at Yalobusha (MP 121.9), and the line passes Hunter (MP 120.6), where CTC resumes, and turns curvily north at Grenada Junction, whence a line once headed northeast to Grenada, past Craigside, Wakeland, the 9,542 ft. siding on the east side at Money (MP 112.8), Ruby, a detector at MP 107.4, Phillip (MP 105.0), where a branch once trailed in from the east and left to the west, and the line turns west (freight speed limit 25 mph on the curve), northwest and then north past Somerville, Black Bayou Junction, where a branch once trailed in from the southwest, Midway, where the line turns northwest, Glendora, where the line turns northeast, Whitehead, where it turns north (freight speed limit 40 mph on the curve), the 10,475 ft. siding on the east side at Swan Lake (MP 93.7), where a line to Clarksdale heads northwest, Mikoma (MP 89.1), Brazil (MP 83.3), a detector at MP 83.1, Stover and Chancy.
There is a 9,600 ft. siding on the east side at Lambert (freight speed limit 40 mph past the siding, and 20 mph in town), where a line once trailed in from the south-southwest, just south of Marks (MP 66.4), and the line continues north past Hinchcliff, Essex, and Darling, northeast past Falcon, Sledge (MP 54.3), and a detector at MP 52.5, north past the 9,860 ft. siding on the west side at Crenshaw (MP 48.8), Askew, Buxton, Sarah (MP 44.1, freight speed 40 mph on curves), the 2,051 ft. siding on the west side at Savage (MP 39.4), Dooley, Prichard (MP 34.6), the 9,940 ft. siding on the east side at Rials (MP 30.2), Lost Lake, Banks (MP 26.9), Marienette, and the 9,553 ft. siding on the west side at Lake Cormorant (MP 20.5), where a branch trails in from the southwest and the line turns northeast (freight speed 25 mph on the curve), past Glover, Walls (MP 15.2), where there is a detector and the line turns north, Lake View (MP 13.1), where Two Main Tracks start (freight speed 25 mph on the switch, and 30 mph thereafter), CTC ends and ABS starts and the line enters Tennessee.
The line (track 2, bidirectionally signaled) turns north-northeast at a location where another line (track 1, signaled for southbound movement only) continues north, and track 2 passes Hulett (MP 7.1) to West Junction (MP 5.4), where track 1 trails in from the west, the passenger route goes northeast through the center of town, along the Mississippi River, while the freight line goes around to the east. The Memphis yard, Johnston Yard, is at the south end of the freight bypass to the east, just east of West Junction.
After passing a loop track on the east side just south of the junction, the passenger line (speed limit 30 mph) rejoins the line from the Grenada District, trailing in from the south, at Y&MV Junction (MP 0.0/394.3), where it turns north, with speed limit 20 mph, past yard tracks and spurs west to the MidSouth terminal and Presidents Island on the west side, to Broadway (MP 392.5), where there are flat crossing and intersections with BNSF (former Frisco), NS and CSX lines to the east, and BNSF (former Frisco) and UP (former MP) lines crossing the river to the west. Amtrak's Memphis Central Station MP 391.8) is just to the north, with double track and speed limit 10 mph from Broadway to MP 391.0, after which the 30 mph single track line turns north-northeast where the erstwhile line from Union Station trailed in, runs briefly along the east bank of the Mississippi River and then the channel east of Mud Island, crosses an erstwhile L&N route, passes North Yard (MP 389.3), where a UP connector turns east, and turns northeast to the north end of the bypass (trailing in from the south) at Woodstock (MP 380.4).
For northbound Amtrak train 58, darkness falls in northern Mississippi, and dawn occurs in central Illinois.