Spuyten-Duyvil to Poughkeepsie

At one time (e.g., in 1990), the Lakeshore Limited and Empire Service trains used the Hudson Line line all the way from Grand Central Terminal. More recently (since before 1996), Amtrak trains come onto the Hudson Line at Spuyten-Duyvil (on the Harlem River), using the west-side line from Penn Station, New York City, at the crossovers at CP 12 (MP 10.8), where it joins the three track, third-rail electrified, Metro-North Hudson Line, coming west along the north bank of the Harlem River and turning north along the river bank at this point with four tracks, speed limit 75 mph for passenger trains and 40 mph for freights. There is a 10,032 ft. siding on the west side of the line at this point. The line passes passenger stations, many of them with two side platforms on the outer tracks only, at Riverdale (MP 13.0, 2 sides), Ludlow (MP 14.4, 2 sides), a road bridge overhead, bridges over streets, a curve with speed limit 50-40, the westernmost track from Grand Central bridging over the line from Penn Station, with the lines now electrified using the third rail, Yonkers (MP 15.2, two islands), Glenwood (MP 16.3, 2 sides and a footbridge), Greystone (MP 17.9, 2 sides and a footbridge), a pedestrian bridge overhead, an industrial facility on the west side (on the east bank of the river), crossovers at CP 19 (MP 18.5), Hastings (MP 19.5, 2 sides, footbridge), Dobbs Ferry (MP 20.7, 2 sides, footbridge), Ardsley (MP 21.8, 2 sides, footbridge), a street to the west, a road bridge overhead, Irvington (MP 22.7, 2 sides), the Tappan Zee Bridge overhead, crossovers at CP 25 (MP 24.7), where the speed limit reduces to 70-40, a street to the west, a road bridge overhead, a "tunnel", Tarrytown (MP 25.3), with platforms on all four tracks, crossovers at CP 26 (MP 26.4), Philipse Manor (MP 26.5, 2 sides), a through truss bridge over an inlet, a road bridge overhead, Scarborough (MP 29.5, 2 sides, footbridge), a cutting with a road bridge overhead, a road bridge overhead, Ossining (MP 30.9, 2 sides), where Sing-Sing State Prison is on the west side of the line and the speed limit reverts to 75-40, a street to the west, a road bridge overhead, crossovers at CP 33 (MP 32.9), where the speed limit falls to 40-25, and a through truss bridge over an inlet, to Croton-Harmon (MP 33.3), another station with platforms on all four tracks (three islands plus footbridge and a signal tower at the north end). Here, the electrified commuter-territory from GCT ends, and the  Metro-North commuter-train shops reside on the west side of the line.

Now non-electrified, the line continues northwest past a road bridge overhead north of the station, a former signal tower on the west side (now used by the Metro-North Communications Department), a pedestrian bridge overhead, a CSX yard on the west side, crossovers at CP 34 (MP 33.4), where the number of tracks reduces to three, MP 34.1, where the speed limit increases to 60-25, crossovers at CP 35 (MP 34.2), Croton North Station (MP 34.6), MP 34.7, where the speed limit increases to 80-45 (and 80-50 at MP 35.7), with various lower limits (non below 45 mph) on curves along the way, a tunnel along the river bank, a turn north away from the river, two road bridges overhead, crossovers at CP 36 (MP 36.4), a curve northwest past Cortlandt (MP 38.4, island plus east side platform, footbridge), and two road bridges overhead, and then north again, past crossovers at CP 40 (MP 40.8), where the three tracks reduce to two and speed fall to 60-40, a factory on the west side, a bridge over a road, a factory on the west side, a road bridge overhead, Peekskill (MP 41,3, island plus east side platform, footbridge), where the line is back on the river bank MP 43, a turn northwest through two tunnels, and then north through another tunnel, which is itself under the Bear Mountain highway bridge, past MP 45.3, where speeds revert to 80-50, a grade crossing, Manitou (MP 46.1), a road bridge overhead, crossovers at CP 48 (MP 48.2), Garrison (MP 49.9, two sides), opposite West Point on the other side of the river, a road bridge overhead, the tracks separating briefly, a bridge over a lagoon as the line turns north-northwest, a path alongside to the west, MP 51.7, where the speed limit rises to 95-50, a parking lot to the west, Cold Spring (MP 52.4, two sides, footbridge), a road bridge overhead, MP 54, paired tunnels, a footbridge overhead, a through girder bridge over an inlet, Breakneck Ridge (MP 55.0), a curve north again, a bridge carrying the Beacon Line overhead from east to northwest and then north, MP 58.4, where speeds become 90-50, CP 58 (MP 58.6), where the Beacon Line trails in on the west side of the line, a road bridge overhead, Beacon (MP 59.0, two island platforms, footbridge), where there is a 13,200 ft. siding on the east side of the line, dual highway bridges overhead (and over the river), crossovers at CP 61 (MP 61.4), a grade crossing to a boat harbor, crossovers at CP 64 (MP 64.8), where there is a through girder moveable bridge, New Hamburg (MP 65.1, two sides), a road bridge overhead, a gravel plant on the west side, MP 71.9, where speeds fall to 70-50, a grade crossing, crossovers at CP 72 (MP 72.5), a street alongside to the west, a road bridge overhead, a road bridge overhead that also crosses the river, a road bridge overhead, and Poughkeepsie station (MP 73.6, two sides, footbridge), where Metro-North diesel-powered commuter services end and there is a 13,700 ft. siding on the east side of the line.

Metro-North ownership ends at CP 75 (MP 75.5), north of the station, beyond where the Poughkeepsie railroad bridge (unused since it burned in 1974) passes high above the line.