Welcome!

This website contains
supplemental materials for the 2^{nd} edition of

Design and
Analysis of Quality of Life Studies in Clinical Trials.

Datasets:

There are six
clinical trials that are used as examples in the book. Four are derived from actual trials; two are
simulated. All are modified to protect
both the trial participants and the sponsors.
I have obtained data use agreements for the four derived from actual
trials for educational use only. I will
ask you to make the same commitment and use the datasets solely for the purpose
of learning the techniques presented in the book.

For each study,
there is a PDF dictionary with variable names, descriptor and coding if
applicable. The datasets ending in 3 contain the merged baseline and
longitudinal data. The datasets are for
SPSS (*3.sav), R (*3.csv), Stata (*3.dta) and SAS
(*3.sas7bdat). There is an additional
SAS format file (format.sas7bdat). For a
few studies, there are two additional SAS datasets separating the baseline data
(*1.sas7bdat) from the longitudinal data (*.2.sas7bdat).

Study 1: Adjuvant
Breast Cancer Trial.

Study 2: Migraine
Prevention Trial.

Study 4: Renal-cell
Carcinoma Trial

Study 5: Chemoradiation (CXRT) Trial

Programs:

The following
sections contain selected programs that are used in the book along with some
additional programs that were omitted due to space constraints.

Chapter 3:
Repeated Measures Models – Study 1 (SAS, SPSS and R)

Chapter 4:
Growth Curve Mixed Effects Models – Study 2 (SAS, SPSS and R)
(Modified 9Sep10)

Chapter 4: Growth
Curve Mixed Effects Models – Study 4 (SAS, SPSS and R)

Chapter 4: Growth
Curve Mixed Effects Models – Study 6 (SAS only)

Chapter 5:
Mediation – Study 2 (SAS only)

Chapter 9: Multiple
Imputation – Study 3 (SAS, SPSS and R)

Chapter 10: Mixture Models – Study 3 (SAS
and R)

Chapter 11: Conditional Linear Model – Study 3 (SAS, SPSS and R)

Chapter 11: Varying Coefficient Model – Study 3 (SAS
only)

Chapter 11: Joint Model – Study 3 (SAS and R)

Chapter 11: Joint Model – Study 6 (SAS only)

Chapter 13: Multiple Comparisons – Study 1 (SAS only)

Chapter 15: Q-TWiST – Study 1
(SAS only)

Chapter 16: Sample Size calculations for RM and GC
studies (SAS only)

Appendix S: Bootstrap Macros (SAS)

If readers are
aware of software capabilities that I am not, I would be happy to add their
programs to this Website.