Problem 13

Imagine that a newly discovered, recessively inherited disease is expressed only in individuals with type O blood, although the disease and blood group are independently inherited. A normal man with type A blood and a normal woman with type B blood have already had one child with the disease. The woman is now pregnant for a second time. What is the probability that the second child will also have the disease? Assume both parents are heterozygous for the "disease" gene.

 

Genotype

Father

AO

Mother

BO

OO expresses the disease

The second child's chance of having the disease is = x = 1/16