June 10, 2014 it was announced a $25,000.00 CADASIL Research Grant was awarded to Fabrice Dabertrand, Ph.D. of the University of Vermont College of Medicine.
Dr. Debertrand, explained what they will be using the grant for: The active regions of the brain trigger rapid and local elevations of blood flow ensure an adequate supply of nutrients and oxygen. This process is known as neurovascular coupling requires a precise communication from astrocytes to arterioles.
Using CADASIL mouse model developed by our collaborator Dr. Anne Joutel, we will test whether the presence of a CADASIL-causing mutation in the NOTCH3 gene alters the communication between astrocytes and arterioles during neurovascular coupling.
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a RARE GENETIC hereditary autosomal dominant disease affecting all the small cerebral arteries. It causes subcortical infarcts and damages the white matter (leukoencephalopathy) and it is due to various mutations of the Notch3 gene situated on chromosome 19. Read more
Professor Hugues Chabriat, the Head of the Department of Neurology in University Hospital Lariboisiere and Coordinator of the Referral Centre for Rare Cerebrovascular Diseases (www.cervco.fr) in Paris, France.
Until CADASIL Together We Have Hope was established in 2005, there was nowhere to turn for assistance and support.
Please take your time to browse through the website. We have compiled a wealth of information and resources through our carefully nurtured relationships and collaboration with a plethora of medical professionals, researchers, and organizations throughout the world. Feel free to download any of the information from the website and forward it on to family members, friends, and especially medical professionals. If you have difficulty finding the information you need let us know.
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CADASIL Together We Have Hope Non-Profit was established on May 10, 2005 as a non-profit organization. The organization has followed the Health On the Net (HON) guidelines, which promotes and guides the deployment of useful and reliable online health information and its appropriate and efficient use. We pledge to continue our efforts to increase awareness, education, and knowledge of this disease with up-to-date information from trustworthy and reliable resources. We require no membership as we are here for you!
We are devoted to promoting advocacy, awareness, education, research and support. We are dedicated to enhancing the established communication network among families as well as identifying sources of medical care and social services. We foster advocacy and open communication among all stakeholders as we work collaboratively to find a treatment or cure for CADASIL. Find out more
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