Calcium Intracellular Messenger System Disruption

A short Introduction

The Calcium Intracellular Messenger System (CIMS) exist in every cell which must respond to a message arriving from outside of itself. The arriving messenger can be one of various chemical molecules. Each kind of receiving cell has receptors which recognize one particular messenger molecule. When it sees one, it opens a channel which allows Calcium ions (Ca++) to flow into the cell.

This Ca++ influx results in chemical activity which causes the cell to do whatever it is supposed to do in response to the message. It also results in turning on a pump which pumps the Ca++ out of the cell.

If this system is disrupted, the cell will not do what is is supposed to do. If it is disrupted in such a way as to prevent the Ca++ pump from working, the Ca++ is not pumped out of the cell. Ca++ accumulates in the cell. These Ca++ combine with various phosphate molecules in the cell. These new molecules are insoluble. The are like little rocks, and are known as "cellular stones."

The excess calcium is also taken up by and engorges the mitochondria. Mitochondria are the little organs inside of cells which are responsible for the proper use of energy by the cell. The writer hypothesizes that the thus engorged mitochondria cannot do their functions as well as normal ones, therefore the cell will be energy starved.

Such damaged cells will eventually be able to dump the cellular stones out of themselves and thus return to normal. Some stones are eliminated immediately in the urine. Because they are insoluble, they turn the urine cloudy. Some seem to attach themselves to nearby bone, producing lumps. Eventually all of the stones are eliminated.

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