The first two chapters center on Strobel’s former belief in the Theory of Evolution, how he arrived at it and how it influenced his philosophy and way life. In particular, Strobel focuses on several "evidences" for macro (inter-species) Evolution that he had found convincing when he was taught about Evolution in high school and college. In the third chapter, Strobel’s interviewee shows that each of these "evidences" are known to be false or even fraudulent. One of them the famous experiment by Stanley Miller purported to demonstrate how amino acids, the basic building blocks of life, could have been formed by natural processes in the "early Earth". The interviewee shows that Miller’s simulation of the environment of the "early Earth" was incorrect. Had the correct environment been used in the experiment, amino acids would not have been formed or would have been broken down by that environment too rapidly to serve as a basis for incipient life. It is also pointed out that, even given amino acids, the chasm from amino acids to life is too great to have been bridged by natural processes. Charles Darwin’s tree of life, which shows how Darwin believed the various phyla and species developed from each other over great periods of time is demonstrated to be false through what is commonly called the "Cambrian Explosion". In the "Cambrian Explosion", most known phyla appear suddenly, without transitional forms, fully formed, within a short geological period of time. This directly and in detail contradicts Darwin’s tree of life concept. The famous drawings by Ernst Haekel purporting to demonstrate common ancestry by showing that embryos of different phyla are nearly identical in early development are shown to be long-known frauds. Haekel’s fraud was exposed in the late 1860s, yet his drawings have been used in textbooks published as recently as 1999 (and may still be used). Strobel’s interviewee also points out the problems with using archaeopteryx as an evidence for macro-Evolution (e.g. that archaeopteryx predates saurian "ancestors" of birds).

Subsequent chapters’ topics include:

A brief review can scarce do justice to this book. It is interesting and informative, demonstrating that Christians not only have nothing to fear in science, but will also find much support and encouragement for their faith. At 292 pages, plus an appendix, study questions (useful for group study and homeschooling), and bibliographical notes, The Case for a Creator provides readers a good over-view of each topic. At the end of each chapter is a list of books for readers desiring more in-depth information on a topic. All in all, The Case for a Creator is a must-read book for Christians who are serious about their faith and want to be better equipped to be witnesses in modern society.