is a compound consisting of the semi-metallic element
gallium (Ga) together with maltol, a naturally occurring constituent of many foods.
In numerous clinical and preclinical trials, gallium has demonstrated
potent antiproliferative, anti-inflammatory, antimicrobial, and anti-bone resorptive activities.
An intravenous form of gallium, gallium nitrate (Ganite®), is currently approved by the FDA
for use in the United States to treat cancer-related hypercalcemia. Intravenous gallium nitrate has also shown clinical efficacy against several forms of cancer, including lymphoma, multiple myeloma, bladder cancer, and prostate cancer. Its use is limited, however, by kidney toxicity, which is reduced through administration by slow intravenous infusion over several days.
Gallium maltolate has been developed as an orally and topically active form of gallium,
designed with the goals of maximizing efficacy while minimizing toxicity. In clinical trials to date,
gallium maltolate has shown no kidney toxicity or other dose-limiting toxicity.
This website contains introductory information on gallium maltolate and on the therapeutic applications of gallium.